Epilepsy
During my brief stint with the clinical neurology department, I worked on epilepsy condition to understand ictogenesis and seizure termination.
Background cortical synchrony
Our research found enhanced background synchrony in patients with epilepsy. This we speculate this might be the reason for increased chances of spontaneous seizure generation in such patients with epilepsy.
Here is my peer reviewed journal paper
Chetan S Nayak, N Mariyappa, K Majumdar, Pradeep D, Ravi GS, Madhu Nagappa, T Kandavel, Arun B Taly, Sanjib Sinha, "Heightened background cortical synchrony in patients with epilepsy", Clinical EEG and Neuroscience, vol. 49(3), pp.177-86, 2018
Link: https://journals.sagepub.com/doi/full/10.1177/1550059417696559
10.1177_1550059417696559.pdfSleep and seizure
Our research indicates that cortical synchrony increases in delta band during non rapid eye movement (non-REM) sleep stage; further cortical synchrony increases in alpha band when awake. We speculate on the role of cortical synchrony in epileptic seizure generation during sleep.
Here is my peer reviewed paper:
Chetan S Nayak, A Bowmik, Pradeep D, Sandipan Pati, KK Choudhury, K Majumdar, "Phase synchronization analysis of wake and sleep EEG of healthy individuals using a novel ensemble phase synchronization measure", Journal of Clinical Neurophysiology, vol. 34 (1), pp. 77-83, 2017
Link: https://journals.lww.com/clinicalneurophys/Abstract/2017/01000/Phase_Synchronization_Analysis_of_Natural_Wake_and.12.aspx
Phase_Synchronization_Analysis_of_Natural_Wake_and.12.pdfAntiepileptic medications
Our research found that cortical synchrony changes with stages of sleep in patients with epilepsy. This work also suggest that the antiepileptic medications accomplishes seizure termination by inhibiting cortical synchrony.
Here is my peer reviewed journal paper
Chetan S Nayak, N Mariyappa, K Majumdar, Ravi GS, Pradeep D, Madhu Nagappa, T Kandavel, Arun B Taly, Sanjib Sinha, "NREM Sleep and antiepileptic medications modulate epileptiform activity by altering cortical synchrony", Clinical EEG and Neuroscience, vol. 49 (6), pp. 417-424, 2018
Link: https://journals.sagepub.com/doi/full/10.1177/1550059417747436
10.1177_1550059417747436.pdf