In my latest paper, I hypothesize that in Misophonia (a condition characterized by intense emotional and physiological reactions to specific human-generated sounds) there is a self-perpetuating cycle of mirror system hyperactivity mediated by iron dysregulation.
Here is the predicted pathological self-perpetuating cycle:
Mirror system hyperactivity → Metabolic stress → Iron accumulation → Inflammation → Impaired inhibition → Involuntary mimicry.
I suggest that therapies aimed at breaking this self-perpetuating loop may offer effective strategies for managing Misophonia.
[1] Pradeep D, Soumita Ramesh, "Is iron dysregulation in the mirror motor cortex associated with misophonia?", Medical Hypotheses, vol. 204, p. 111765, Nov 2025.